Formulation and evaluation of a bioadhesive patch for buccal delivery of tizanidine
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چکیده
منابع مشابه
A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods
Owing to the ease of the administration, the oral cavity is an attractive site for the delivery of drugs. Through this route it is possible to realize mucosal (local effect) and transmucosal (systemic effect) drug administration. In the first case, the aim is to achieve a site-specific release of the drug on the mucosa, whereas the second case involves drug absorption through the mucosal barrie...
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In recent years growing attention has been paid to the nasal drug administration as an alternative route of administration for systemically active drugs such as proteins, peptides, hormones, and other drugs which are poorly absorbed orally and extensively metabolized in liver. Nasal route is easily accessible, convenient and reliable route with a porous endothelial membrane and a highly vascula...
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In this study, tretinoin microemulsion has been formulated based on phase diagram studies by changing the amounts and proportions of inactive ingredients, such as surfactants, co-surfactants and oils. The effects of these variables have been determined on microemulsion formation, particle size of the dispersed phase and release profile of tretinoin from microemulsion through dialysis membrane. ...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica Sinica B
سال: 2012
ISSN: 2211-3835
DOI: 10.1016/j.apsb.2011.12.012